Lack of toxicity of a STAT3 decoy oligonucleotide

BACKGROUND: STAT3 overexpression has been detected in several cancers including head and neck squamous cell carcinoma (HNSCC). Previous studies using intratumoral administration of a STAT3 decoy oligonucleotide that abrogates STAT3-mediated gene transcription in preclinical cancer models have demons...

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Détails bibliographiques
Auteurs principaux: Sen, Malabika, Tosca, Patricia J., Zwayer, Christa, Ryan, Michael J., Johnson, Jerry D., Knostman, Katherine A. B., Giclas, Patricia C., Peggins, James O., Tomaszewski, Joseph E., McMurray, Timothy P., Li, Changyou, Leibowitz, Michael S., Ferris, Robert L., Gooding, William E., Thomas, Sufi M., Johnson, Daniel E., Grandis, Jennifer R.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422883/
https://ncbi.nlm.nih.gov/pubmed/18766340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0823-6
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