Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity

BACKGROUND: Gain-of-function mutations of tyrosine kinase FLT3 are frequently found in acute myeloid leukemia (AML). This has made FLT3 an important marker for disease diagnosis and a highly attractive target for therapeutic drug development. This study is intended to generate a sensitive substrate...

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Main Authors: Chen, Yun, Guo, Yao, Han, Jiayu, Ho, Wanting Tina, Li, Shibo, Fu, Xueqi, Zhao, Zhizhuang Joe
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
主題:
Rapid Communication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419602/
https://ncbi.nlm.nih.gov/pubmed/22800464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-39
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