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Identification of an orally available compound with potent and broad FLT3 inhibition activity
FLT3 internal tandem duplication (FLT3-ITD) is an activating mutation found in 20%-30% of patients with acute myeloid leukemia (AML), which makes FLT3 an attractive target for the treatment of AML. Although FLT3-mutant patients respond to current FLT3 inhibitors, relapse usually happens due to the a...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4809803/ https://ncbi.nlm.nih.gov/pubmed/26411368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.362 |
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