New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer’s disease

BACKGROUND: Amyloid precursor protein (APP), a key molecule in Alzheimer’s disease (AD), is metabolized in two alternative cleavages, generating either the amyloidogenic peptides involved in AD pathology or the soluble form of APP (sAPPα). The level of amyloidogenic peptides in human cerebrospinal f...

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Bibliografische gegevens
Hoofdauteurs: Rose, Christiane, Peoc’h, Katell, Chasseigneaux, Stéphanie, Paquet, Claire, Dumurgier, Julien, Bourasset, Fanchon, Calon, Frédéric, Laplanche, Jean-Louis, Hugon, Jacques, Allinquant, Bernadette
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Methodology Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418197/
https://ncbi.nlm.nih.gov/pubmed/22824057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-13-84
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