New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer’s disease

BACKGROUND: Amyloid precursor protein (APP), a key molecule in Alzheimer’s disease (AD), is metabolized in two alternative cleavages, generating either the amyloidogenic peptides involved in AD pathology or the soluble form of APP (sAPPα). The level of amyloidogenic peptides in human cerebrospinal f...

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Détails bibliographiques
Auteurs principaux: Rose, Christiane, Peoc’h, Katell, Chasseigneaux, Stéphanie, Paquet, Claire, Dumurgier, Julien, Bourasset, Fanchon, Calon, Frédéric, Laplanche, Jean-Louis, Hugon, Jacques, Allinquant, Bernadette
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Methodology Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418197/
https://ncbi.nlm.nih.gov/pubmed/22824057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-13-84
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