Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme

Most of the small ribozymes, including those that have been investigated as potential therapeutic agents, appear to be rather poor catalysts. These RNAs use an internal phosphoester transfer mechanism to catalyze site-specific RNA cleavage with apparent cleavage rate constants typically <2 min(-1)....

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Zamel, Ricardo, Poon, Alan, Jaikaran, Dominic, Andersen, Angela, Olive, Joan, De Abreu, Diane, Collins, Richard A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2004
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14755053/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305753101
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