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Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme

Most of the small ribozymes, including those that have been investigated as potential therapeutic agents, appear to be rather poor catalysts. These RNAs use an internal phosphoester transfer mechanism to catalyze site-specific RNA cleavage with apparent cleavage rate constants typically <2 min(-1...

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Bibliografske podrobnosti
Main Authors: Zamel, Ricardo, Poon, Alan, Jaikaran, Dominic, Andersen, Angela, Olive, Joan, De Abreu, Diane, Collins, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC341743/
https://ncbi.nlm.nih.gov/pubmed/14755053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305753101
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