Functional involvement of G8 in the hairpin ribozyme cleavage mechanism

The catalytic determinants for the cleavage and ligation reactions mediated by the hairpin ribozyme are integral to the polyribonucleotide chain. We describe experiments that place G8, a critical guanosine, at the active site, and point to an essential role in catalysis. Cross-linking and modeling s...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Pinard, Robert, Hampel, Ken J., Heckman, Joyce E., Lambert, Dominic, Chan, Philip A., Major, Francois, Burke, John M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6434
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