Safer, Silencing-Resistant Lentiviral Vectors: Optimization of the Ubiquitous Chromatin-Opening Element through Elimination of Aberrant Splicing

Gammaretroviral and lentiviral vectors have been used successfully in several clinical gene therapy trials, although powerful enhancer elements have caused insertional mutagenesis and clonal dysregulation. Self-inactivating vectors with internal heterologous regulatory elements have been developed a...

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Main Authors: Knight, Sean, Zhang, Fang, Mueller-Kuller, Uta, Bokhoven, Marieke, Gupta, Abhinav, Broughton, Thomas, Sha, Sha, Antoniou, Michael N., Brendel, Christian, Grez, Manuel, Thrasher, Adrian J., Collins, Mary, Takeuchi, Yasuhiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Gene Delivery
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416147/
https://ncbi.nlm.nih.gov/pubmed/22696657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00485-12
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