Safer, Silencing-Resistant Lentiviral Vectors: Optimization of the Ubiquitous Chromatin-Opening Element through Elimination of Aberrant Splicing

Gammaretroviral and lentiviral vectors have been used successfully in several clinical gene therapy trials, although powerful enhancer elements have caused insertional mutagenesis and clonal dysregulation. Self-inactivating vectors with internal heterologous regulatory elements have been developed a...

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Detalhes bibliográficos
Main Authors: Knight, Sean, Zhang, Fang, Mueller-Kuller, Uta, Bokhoven, Marieke, Gupta, Abhinav, Broughton, Thomas, Sha, Sha, Antoniou, Michael N., Brendel, Christian, Grez, Manuel, Thrasher, Adrian J., Collins, Mary, Takeuchi, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416147/
https://ncbi.nlm.nih.gov/pubmed/22696657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00485-12
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