Insertional Gene Activation by Lentiviral and Gammaretroviral Vectors

Gammaretroviral and lentiviral vectors are promising tools for gene therapy, but they can be oncogenic. The development of safer vectors depends on a quantitative assay for insertional mutagenesis. Here we report a rapid, inexpensive, and reproducible assay which uses a murine cell line to measure t...

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Detalles Bibliográficos
Main Authors: Bokhoven, Marieke, Stephen, Sam L., Knight, Sean, Gevers, Evelien F., Robinson, Iain C., Takeuchi, Yasuhiro, Collins, Mary K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Gene Delivery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612344/
https://ncbi.nlm.nih.gov/pubmed/18945765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01865-08
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