A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells

Epigenetic silencing of transgene expression represents a major obstacle for the efficient genetic modification of multipotent and pluripotent stem cells. We and others have demonstrated that a 1.5 kb methylation-free CpG island from the human HNRPA2B1-CBX3 housekeeping genes (A2UCOE) effectively pr...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Müller-Kuller, Uta, Ackermann, Mania, Kolodziej, Stephan, Brendel, Christian, Fritsch, Jessica, Lachmann, Nico, Kunkel, Hana, Lausen, Jörn, Schambach, Axel, Moritz, Thomas, Grez, Manuel
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330381/
https://ncbi.nlm.nih.gov/pubmed/25605798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv019
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