A Ubiquitous Chromatin Opening Element (UCOE) Confers Resistance to DNA Methylation–mediated Silencing of Lentiviral Vectors

DNA methylation may restrict the activity of gene transfer vectors due to inadvertent silencing. In P19 embryonic carcinoma cells in vitro, we found that transgene expression regulated by the SFFV LTR and EF1α promoter declined rapidly within 16 days, but for A2UCOE derived from the human HNRPA2B1-C...

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Detalhes bibliográficos
Main Authors: Zhang, Fang, Frost, Amy R, Blundell, Mike P, Bales, Olivia, Antoniou, Michael N, Thrasher, Adrian J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956914/
https://ncbi.nlm.nih.gov/pubmed/20588258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.132
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