Biophysical Characterization of Met-G-CSF: Effects of Different Site-Specific Mono-Pegylations on Protein Stability and Aggregation

The limited stability of proteins in vitro and in vivo reduces their conversion into effective biopharmaceuticals. To overcome this problem several strategies can be exploited, as the conjugation of the protein of interest with polyethylene glycol, in most cases, improves its stability and pharmacok...

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Hlavní autoři: Natalello, Antonino, Ami, Diletta, Collini, Maddalena, D’Alfonso, Laura, Chirico, Giuseppe, Tonon, Giancarlo, Scaramuzza, Silvia, Schrepfer, Rodolfo, Doglia, Silvia Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414461/
https://ncbi.nlm.nih.gov/pubmed/22905140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042511
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