Biophysical Characterization of Met-G-CSF: Effects of Different Site-Specific Mono-Pegylations on Protein Stability and Aggregation

The limited stability of proteins in vitro and in vivo reduces their conversion into effective biopharmaceuticals. To overcome this problem several strategies can be exploited, as the conjugation of the protein of interest with polyethylene glycol, in most cases, improves its stability and pharmacok...

詳細記述

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書誌詳細
主要な著者: Natalello, Antonino, Ami, Diletta, Collini, Maddalena, D’Alfonso, Laura, Chirico, Giuseppe, Tonon, Giancarlo, Scaramuzza, Silvia, Schrepfer, Rodolfo, Doglia, Silvia Maria
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414461/
https://ncbi.nlm.nih.gov/pubmed/22905140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042511
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