Biophysical Characterization of Met-G-CSF: Effects of Different Site-Specific Mono-Pegylations on Protein Stability and Aggregation

The limited stability of proteins in vitro and in vivo reduces their conversion into effective biopharmaceuticals. To overcome this problem several strategies can be exploited, as the conjugation of the protein of interest with polyethylene glycol, in most cases, improves its stability and pharmacok...

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Detalhes bibliográficos
Main Authors: Natalello, Antonino, Ami, Diletta, Collini, Maddalena, D’Alfonso, Laura, Chirico, Giuseppe, Tonon, Giancarlo, Scaramuzza, Silvia, Schrepfer, Rodolfo, Doglia, Silvia Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414461/
https://ncbi.nlm.nih.gov/pubmed/22905140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042511
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