Enzymatic mono-pegylation of glucagon-like peptide 1 towards long lasting treatment of type 2 diabetes

Human glucagon-like peptide-1 (GLP-1) is a physiological gastrointestinal peptide with glucose-dependent insulinotropic effects which is therefore considered an interesting antidiabetic agent. However, after in vivo administration, exogenous GLP-1 does not exert its physiological action due to the c...

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Main Authors: Selis, Fabio, Schrepfer, Rodolfo, Sanna, Riccardo, Scaramuzza, Silvia, Tonon, Giancarlo, Dedoni, Simona, Onali, Pierluigi, Orsini, Gaetano, Genovese, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167179/
https://ncbi.nlm.nih.gov/pubmed/25755995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.rinphs.2012.09.001
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