Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

PEGylation of biomolecules is a major approach to increase blood stream half-life, stability and solubility of biotherapeutics and to reduce their immunogenicity, aggregation potential and unspecific interactions with other proteins and tissues. Antibodies have generally long half-lives due to high...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Selis, Fabio, Focà, Giuseppina, Sandomenico, Annamaria, Marra, Carla, Di Mauro, Concetta, Saccani Jotti, Gloria, Scaramuzza, Silvia, Politano, Annalisa, Sanna, Riccardo, Ruvo, Menotti, Tonon, Giancarlo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848947/
https://ncbi.nlm.nih.gov/pubmed/27043557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17040491
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