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Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y(6) nucleotide receptors

The physiological role of the P2Y(6) nucleotide receptor may involve cardiovascular, immune and digestive functions based on the receptor tissue distribution, and selective antagonists for this receptor are lacking. We have synthesized a series of symmetric aryl diisothiocyanate derivatives and exam...

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Autors principals: Mamedova, Liaman K., Joshi, Bhalchandra V., Gao, Zhan-Guo, von Kügelgen, Ivar, Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413726/
https://ncbi.nlm.nih.gov/pubmed/15081875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2004.01.011
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