Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not understood. We have generated mice with targeted disruption of Cul4b, and observed embryonic...

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Detalhes bibliográficos
Main Authors: Liu, Liren, Yin, Yan, Li, Yuewei, Prevedel, Lisa, Lacy, Elizabeth H, Ma, Liang, Zhou, Pengbo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411166/
https://ncbi.nlm.nih.gov/pubmed/22453236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.48
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