Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not understood. We have generated mice with targeted disruption of Cul4b, and observed embryonic...

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Autors principals: Liu, Liren, Yin, Yan, Li, Yuewei, Prevedel, Lisa, Lacy, Elizabeth H, Ma, Liang, Zhou, Pengbo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411166/
https://ncbi.nlm.nih.gov/pubmed/22453236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.48
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