Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer

The Cullin-RING ubiquitin ligase 4 (CRL4) is implicated in controlling cell cycle, DNA damage repair, and checkpoint response based on studies employing cell lines and mouse models. CRL4 proteins, including CUL4A and CUL4B, are often highly accumulated in human malignancies. Elevated CRL4 attenuates...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Jia, Lei, Yan, Fan, Cao, Wenfeng, Chen, Zhengming, Zheng, Hong, Li, Haixin, Pan, Yi, Narula, Navneet, Ren, Xiubao, Li, Hui, Zhou, Pengbo
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314191/
https://ncbi.nlm.nih.gov/pubmed/27974468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.765230
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