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Speed, dissipation, and error in kinetic proofreading

Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between pro...

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Autori principali: Murugan, Arvind, Huse, David A., Leibler, Stanislas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409783/
https://ncbi.nlm.nih.gov/pubmed/22786930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119911109
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