Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D(2) receptor-induced inhibition of NADPH oxidase

The dopamine D(2) receptor (D(2)R) regulates renal reactive oxygen species (ROS) production and impaired D(2)R function results in ROS-dependent hypertension. Paraoxonase 2 (PON2), which belongs to the paraoxonase gene family, is expressed in various tissues, acting to protect against cellular oxida...

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Detalhes bibliográficos
Main Authors: Yang, Yu, Zhang, Yanrong, Cuevas, Santiago, Villar, Van Anthony, Escano, Crisanto, Asico, Laureano, Yu, Peiying, Grandy, David K., Felder, Robin A., Armando, Ines, Jose, Pedro A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408834/
https://ncbi.nlm.nih.gov/pubmed/22634053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.05.015
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