The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCF(β-TrCP)-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

The Hippo tumor suppressor pathway plays a major role in development and organ size control, and its dysregulation contributes to tumorigenesis. TAZ (transcriptional co-activator with PDZ-binding motif; also known as WWTR1) is a transcription co-activator acting downstream of the Hippo pathway, and...

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Hlavní autoři: Huang, Wei, Lv, Xianbo, Liu, Chenying, Zha, Zhengyu, Zhang, Heng, Jiang, Ying, Xiong, Yue, Lei, Qun-Ying, Guan, Kun-Liang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406709/
https://ncbi.nlm.nih.gov/pubmed/22692215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382036
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