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The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCF(β-TrCP)-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition
The Hippo tumor suppressor pathway plays a major role in development and organ size control, and its dysregulation contributes to tumorigenesis. TAZ (transcriptional co-activator with PDZ-binding motif; also known as WWTR1) is a transcription co-activator acting downstream of the Hippo pathway, and...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406709/ https://ncbi.nlm.nih.gov/pubmed/22692215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382036 |
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