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Structure activity relationship of uridine 5′-diphosphate analogues at the human P2Y(6) receptor

The structure activity relationships and molecular modeling of the uracil nucleotide-activated P2Y(6) receptor have been studied. A series of UDP analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosphate group was synthesized and assayed for activity at the human P2Y...

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Autors principals: Besada, Pedro, Shin, Dae Hong, Costanzi, Stefano, Ko, Hyojin, Mathé, Christophe, Gagneron, Julien, Gosselin, Gilles, Maddileti, Savitri, Harden, T. Kendall, Jacobsona, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405152/
https://ncbi.nlm.nih.gov/pubmed/16942026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060485n
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