THERMAL INSTABILITY OF ΔF508 CFTR CHANNEL FUNCTION: PROTECTION BY SINGLE SUPPRESSOR MUTATIONS AND INHIBITING CHANNEL ACTIVITY

Deletion of Phe508 from CFTR results in a temperature-sensitive folding defect that impairs protein maturation and chloride channel function. Both of these adverse effects, however, can be mitigated to varying extents by second-site, suppressor mutations. To better understand the impact of second-si...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Liu, Xuehong, O’Donnell, Nicolette, Landstrom, Allison, Skach, William R., Dawson, David C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402225/
https://ncbi.nlm.nih.gov/pubmed/22680785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300018e
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items