THERMAL INSTABILITY OF ΔF508 CFTR CHANNEL FUNCTION: PROTECTION BY SINGLE SUPPRESSOR MUTATIONS AND INHIBITING CHANNEL ACTIVITY

Deletion of Phe508 from CFTR results in a temperature-sensitive folding defect that impairs protein maturation and chloride channel function. Both of these adverse effects, however, can be mitigated to varying extents by second-site, suppressor mutations. To better understand the impact of second-si...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Liu, Xuehong, O’Donnell, Nicolette, Landstrom, Allison, Skach, William R., Dawson, David C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402225/
https://ncbi.nlm.nih.gov/pubmed/22680785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300018e
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk