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Collaborative coupling between polymerase and helicase for leading-strand synthesis
Rapid and processive leading-strand DNA synthesis in the bacteriophage T4 system requires functional coupling between the helicase and the holoenzyme, consisting of the polymerase and trimeric clamp loaded by the clamp loader. We investigated the mechanism of this coupling on a DNA hairpin substrate...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401439/ https://ncbi.nlm.nih.gov/pubmed/22434886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks254 |
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