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Collaborative coupling between polymerase and helicase for leading-strand synthesis

Rapid and processive leading-strand DNA synthesis in the bacteriophage T4 system requires functional coupling between the helicase and the holoenzyme, consisting of the polymerase and trimeric clamp loaded by the clamp loader. We investigated the mechanism of this coupling on a DNA hairpin substrate...

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Detalles Bibliográficos
Main Authors: Manosas, Maria, Spiering, Michelle M., Ding, Fangyuan, Croquette, Vincent, Benkovic, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401439/
https://ncbi.nlm.nih.gov/pubmed/22434886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks254
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