Collaborative coupling between polymerase and helicase for leading-strand synthesis

Rapid and processive leading-strand DNA synthesis in the bacteriophage T4 system requires functional coupling between the helicase and the holoenzyme, consisting of the polymerase and trimeric clamp loaded by the clamp loader. We investigated the mechanism of this coupling on a DNA hairpin substrate...

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Bibliographic Details
Main Authors: Manosas, Maria, Spiering, Michelle M., Ding, Fangyuan, Croquette, Vincent, Benkovic, Stephen J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401439/
https://ncbi.nlm.nih.gov/pubmed/22434886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks254
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