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Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum
PURPOSE: To detect and characterize the aggregation of therapeutic monoclonal antibodies in undiluted biological fluids. METHODS: Fluorescently labeled subvisible IgG aggregates formed by applying either heat stress or by pH-shift were investigated immediately after addition to human serum, and afte...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer US
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3399096/ https://ncbi.nlm.nih.gov/pubmed/22467219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0749-x |
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