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Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum

PURPOSE: To detect and characterize the aggregation of therapeutic monoclonal antibodies in undiluted biological fluids. METHODS: Fluorescently labeled subvisible IgG aggregates formed by applying either heat stress or by pH-shift were investigated immediately after addition to human serum, and afte...

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Bibliografiske detaljer
Main Authors: Filipe, Vasco, Poole, Robert, Oladunjoye, Olubukayo, Braeckmans, Kevin, Jiskoot, Wim
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399096/
https://ncbi.nlm.nih.gov/pubmed/22467219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0749-x
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