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Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice
The presence of protein aggregates in biopharmaceutical formulations is of great concern for safety and efficacy reasons. The aim of this study was to correlate the type and amount of IgG monoclonal antibody aggregates with their immunogenic potential. IgG degradation was obtained by freeze-thawing...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Landes Bioscience
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502241/ https://ncbi.nlm.nih.gov/pubmed/22951518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22066 |
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