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Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

The presence of protein aggregates in biopharmaceutical formulations is of great concern for safety and efficacy reasons. The aim of this study was to correlate the type and amount of IgG monoclonal antibody aggregates with their immunogenic potential. IgG degradation was obtained by freeze-thawing...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Filipe, Vasco, Jiskoot, Wim, Basmeleh, Abdul Hafid, Halim, Andhyk, Schellekens, Huub, Brinks, Vera
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502241/
https://ncbi.nlm.nih.gov/pubmed/22951518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22066
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