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Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

The presence of protein aggregates in biopharmaceutical formulations is of great concern for safety and efficacy reasons. The aim of this study was to correlate the type and amount of IgG monoclonal antibody aggregates with their immunogenic potential. IgG degradation was obtained by freeze-thawing...

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Autori principali: Filipe, Vasco, Jiskoot, Wim, Basmeleh, Abdul Hafid, Halim, Andhyk, Schellekens, Huub, Brinks, Vera
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502241/
https://ncbi.nlm.nih.gov/pubmed/22951518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22066
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