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Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

The presence of protein aggregates in biopharmaceutical formulations is of great concern for safety and efficacy reasons. The aim of this study was to correlate the type and amount of IgG monoclonal antibody aggregates with their immunogenic potential. IgG degradation was obtained by freeze-thawing...

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Main Authors: Filipe, Vasco, Jiskoot, Wim, Basmeleh, Abdul Hafid, Halim, Andhyk, Schellekens, Huub, Brinks, Vera
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502241/
https://ncbi.nlm.nih.gov/pubmed/22951518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22066
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