Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice

PURPOSE: To study the effect of oxidation on the structure of recombinant human interferon beta-1a (rhIFNβ-1a) and its immunogenicity in wild-type and immune-tolerant transgenic mice. METHODS: Untreated rhIFNβ-1a was degraded by metal-catalyzed oxidation, H(2)O(2)-mediated oxidation, and guanidine-m...

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Autori principali: van Beers, Miranda M. C., Sauerborn, Melody, Gilli, Francesca, Brinks, Vera, Schellekens, Huub, Jiskoot, Wim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170469/
https://ncbi.nlm.nih.gov/pubmed/21544687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0451-4
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