Arrestin Scaffolds NHERF1 to the P2Y(12) Receptor to Regulate Receptor Internalization

We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y(12) receptor (P2Y(12)R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a m...

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Bibliographische Detailangaben
Hauptverfasser: Nisar, Shaista P., Cunningham, Margaret, Saxena, Kunal, Pope, Robert J., Kelly, Eamonn, Mundell, Stuart J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397875/
https://ncbi.nlm.nih.gov/pubmed/22610101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347104
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