Inverse agonism at the P2Y(12) receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

Ticagrelor is a potent antagonist of the P2Y(12) receptor (P2Y(12)R) and consequently an inhibitor of platelet activity effective in the treatment of atherothrombosis. Here, we sought to further characterize its molecular mechanism of action. Initial studies showed that ticagrelor promoted a greater...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Aungraheeta, Riyaad, Conibear, Alexandra, Butler, Mark, Kelly, Eamonn, Nylander, Sven, Mumford, Andrew, Mundell, Stuart J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2016
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161012/
https://ncbi.nlm.nih.gov/pubmed/27694321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707844
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