Inverse agonism at the P2Y(12) receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

Ticagrelor is a potent antagonist of the P2Y(12) receptor (P2Y(12)R) and consequently an inhibitor of platelet activity effective in the treatment of atherothrombosis. Here, we sought to further characterize its molecular mechanism of action. Initial studies showed that ticagrelor promoted a greater...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Aungraheeta, Riyaad, Conibear, Alexandra, Butler, Mark, Kelly, Eamonn, Nylander, Sven, Mumford, Andrew, Mundell, Stuart J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2016
Gaiak:
Thrombosis and Hemostasis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161012/
https://ncbi.nlm.nih.gov/pubmed/27694321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707844
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