Inverse agonism at the P2Y(12) receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

Ticagrelor is a potent antagonist of the P2Y(12) receptor (P2Y(12)R) and consequently an inhibitor of platelet activity effective in the treatment of atherothrombosis. Here, we sought to further characterize its molecular mechanism of action. Initial studies showed that ticagrelor promoted a greater...

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Vydáno v:Blood
Hlavní autoři: Aungraheeta, Riyaad, Conibear, Alexandra, Butler, Mark, Kelly, Eamonn, Nylander, Sven, Mumford, Andrew, Mundell, Stuart J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161012/
https://ncbi.nlm.nih.gov/pubmed/27694321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707844
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