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Inverse agonism at the P2Y(12) receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor
Ticagrelor is a potent antagonist of the P2Y(12) receptor (P2Y(12)R) and consequently an inhibitor of platelet activity effective in the treatment of atherothrombosis. Here, we sought to further characterize its molecular mechanism of action. Initial studies showed that ticagrelor promoted a greater...
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| Vydáno v: | Blood |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161012/ https://ncbi.nlm.nih.gov/pubmed/27694321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707844 |
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