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Identifying mechanism-of-action targets for drugs and probes
Notwithstanding their key roles in therapy and as biological probes, 7% of approved drugs are purported to have no known primary target, and up to 18% lack a well-defined mechanism of action. Using a chemoinformatics approach, we sought to “de-orphanize” drugs that lack primary targets. Surprisingly...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396511/ https://ncbi.nlm.nih.gov/pubmed/22711801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204524109 |
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