Identifying mechanism-of-action targets for drugs and probes

Notwithstanding their key roles in therapy and as biological probes, 7% of approved drugs are purported to have no known primary target, and up to 18% lack a well-defined mechanism of action. Using a chemoinformatics approach, we sought to “de-orphanize” drugs that lack primary targets. Surprisingly...

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Библиографические подробности
Главные авторы: Gregori-Puigjané, Elisabet, Setola, Vincent, Hert, Jérôme, Crews, Brenda A., Irwin, John J., Lounkine, Eugen, Marnett, Lawrence, Roth, Bryan L., Shoichet, Brian K.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396511/
https://ncbi.nlm.nih.gov/pubmed/22711801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204524109
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