GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Proteolytic processing of the amyloid-β precursor protein (APP) and generation of amyloid-β peptide (Aβ) are key events in Alzheimer's disease (AD) pathogenesis. Cell biological and genetic evidence has implicated the low-density lipoprotein and sorting receptor LR11/SorLA in AD through mechani...

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Bibliographic Details
Main Authors: Herskowitz, Jeremy H., Offe, Katrin, Deshpande, Aniruddha, Kahn, Richard A., Levey, Allan I., Lah, James J.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395654/
https://ncbi.nlm.nih.gov/pubmed/22621900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-01-0014
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