Neuronal LR11/SorLA Expression Is Reduced in Mild Cognitive Impairment

OBJECTIVE: LR11 (aka sorLA) is a multifunctional neuronal receptor that binds apolipoprotein E and interacts with amyloid precursor protein to regulate amyloidogenesis. Reduced expression of LR11, as occurs in the brains of individuals with Alzheimer’s disease (AD), increases amyloidogenesis, and va...

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Autores principales: Sager, Kristen L., Wuu, Joanne, Leurgans, Susan E., Rees, Howard D., Gearing, Marla, Mufson, Elliott J., Levey, Allan I., Lah, James J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669325/
https://ncbi.nlm.nih.gov/pubmed/17721864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21190
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