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GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production
Proteolytic processing of the amyloid-β precursor protein (APP) and generation of amyloid-β peptide (Aβ) are key events in Alzheimer's disease (AD) pathogenesis. Cell biological and genetic evidence has implicated the low-density lipoprotein and sorting receptor LR11/SorLA in AD through mechani...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Cell Biology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395654/ https://ncbi.nlm.nih.gov/pubmed/22621900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-01-0014 |
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