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Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance

Resistance to trimethoprim (TMP) resulting from point mutations in the enzyme drug target dihydrofolate reductase (DHFR) drives the development of new antifolate inhibitors effective against methicillin-resistant Staphlococcus aureus (MRSA). For the past several years we have used structure-based de...

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Bibliografske podrobnosti
Main Authors: Frey, Kathleen M., Viswanathan, Kishore, Wright, Dennis L., Anderson, Amy C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393473/
https://ncbi.nlm.nih.gov/pubmed/22491688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06263-11
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