Caricamento...

Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance

Resistance to trimethoprim (TMP) resulting from point mutations in the enzyme drug target dihydrofolate reductase (DHFR) drives the development of new antifolate inhibitors effective against methicillin-resistant Staphlococcus aureus (MRSA). For the past several years we have used structure-based de...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Frey, Kathleen M., Viswanathan, Kishore, Wright, Dennis L., Anderson, Amy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393473/
https://ncbi.nlm.nih.gov/pubmed/22491688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06263-11
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !