Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance

Resistance to trimethoprim (TMP) resulting from point mutations in the enzyme drug target dihydrofolate reductase (DHFR) drives the development of new antifolate inhibitors effective against methicillin-resistant Staphlococcus aureus (MRSA). For the past several years we have used structure-based de...

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Bibliografiska uppgifter
Huvudupphovsmän: Frey, Kathleen M., Viswanathan, Kishore, Wright, Dennis L., Anderson, Amy C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393473/
https://ncbi.nlm.nih.gov/pubmed/22491688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06263-11
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