Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

PSI-352938 is a novel cyclic phosphate prodrug of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine-5′-monophosphate with potent anti-HCV activity. In order to inhibit the NS5B RNA-dependent RNA polymerase, PSI-352938 must be metabolized to the active triphosphate form, PSI-352666. During in vitro inc...

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Autores principales: Niu, Congrong, Tolstykh, Tatiana, Bao, Haiying, Park, Yeojin, Babusis, Darius, Lam, Angela M., Bansal, Shalini, Du, Jinfa, Chang, Wonsuk, Reddy, P. Ganapati, Zhang, Hai-Ren, Woolley, Joseph, Wang, Li-Quan, Chao, Piyun B., Ray, Adrian S., Otto, Michael J., Sofia, Michael J., Furman, Phillip A., Murakami, Eisuke
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393470/
https://ncbi.nlm.nih.gov/pubmed/22526308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00530-12
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