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Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis: Dihydropyridopyrazole Analogues of Podophyllotoxin
[Image: see text] A three-component condensation of 5-amino-3-methylpyrazole, tetronic acid and various aromatic, heteroaromatic and aliphatic aldehydes leads to the formation of dihydropyridopyrazole analogues of a cytotoxic lignan podophyllotoxin. This new heterocyclic scaffold-based library allow...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393043/ https://ncbi.nlm.nih.gov/pubmed/17188868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.11.095 |
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